Mus musculus Gene: Eif5b
Summary
InnateDB Gene IDBG-146623.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif5b
Gene Name eukaryotic translation initiation factor 5B
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000026083
Encoded Proteins
eukaryotic translation initiation factor 5B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158417:
Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:37998010-38055579
Strand Forward strand
Band B
Transcripts
ENSMUST00000027252 ENSMUSP00000027252
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006413 translational initiation
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Translation pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Eukaryotic Translation Initiation pathway
Gene Expression pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
KEGG
RNA transport pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Eukaryotic Translation Initiation pathway
Translation pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Gene Expression pathway
KEGG
RNA transport pathway
INOH
PID BIOCARTA
Eukaryotic protein translation [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.260943
RefSeq NM_198303 XM_006495911
OMIM
CCDS CCDS35544
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas