|Homo sapiens Gene: GATA6|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||GATA binding protein 6|
GATA binding protein 6
|Useful resources||Stemformatics EHFPI ImmGen|
GATA6 activates the transcription of hepcidin antimicrobial peptide in hepatocytes Friend of GATA (FOG)-proteins ZFPM1 and ZFPM2 moderate this transcription by suppressing the GATA transactivation of hepcidin promoter.
|InnateDB Annotation from Orthologs|
[Mus musculus] Gata6 activates the transcription of hepcidin antimicrobial peptide in hepatocytes. Friend of GATA (FOG)-proteins ZFPM1 and ZFPM2 moderate this transcription by suppressing the GATA transactivation of hepcidin promoter. (Demonstrated in human)
This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012]
|Genomic Location||Chromosome 18:22169443-22202528|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Not yet available
Factors involved in megakaryocyte development and platelet production pathway
Notch-mediated HES/HEY network
|UniProt Splice Variant|
|EMBL||AC091588 BC027891 CH471088 D87811 EF444980 U66075 X95701|
|GenPept||AAC50941 AAH27891 ACA05995 BAA22621 CAA64997 EAX01137|
|RNA Seq Atlas||2627|