Version 5.4
Mus musculus Gene: Prkd2
Summary
InnateDB Gene IDBG-147053.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prkd2
Gene Name protein kinase D2
Synonyms AI325941; PKD2
Species Mus musculus
Ensembl Gene ENSMUSG00000041187
Encoded Proteins
IDBP-147055
protein kinase D2
IDBP-622718
protein kinase D2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105287:
The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:16842902-16870461
Strand Forward strand
Band A2
Transcripts
ENSMUST00000086104 ENSMUSP00000083273
ENSMUST00000168093 ENSMUSP00000131192
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004697 protein kinase C activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006468 protein phosphorylation
GO:0007155 cell adhesion
GO:0008219 cell death
GO:0010595 positive regulation of endothelial cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032743 positive regulation of interleukin-2 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032793 positive regulation of CREB transcription factor activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0050862 positive regulation of T cell receptor signaling pathway
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:1901727 positive regulation of histone deacetylase activity
GO:1902533 positive regulation of intracellular signal transduction
GO:2000573 positive regulation of DNA biosynthetic process
GO:2001028 positive regulation of endothelial cell chemotaxis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105287
View Gene Order
ENSBTAG00000015599
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8BZ03
TrEMBL
UniProt Splice Variant
Entrez Gene 101540
UniGene Mm.1881
RefSeq NM_001252458 XM_006539444 NM_178900
OMIM
CCDS CCDS20855
HPRD
IMGT
MGI ID MGI:2141917
MGI Symbol Prkd2
EMBL AK037030 AK154029 AK170236 AK170761 BC095949 BC096444
GenPept AAH95949 AAH96444 BAC29677 BAE32326 BAE41652 BAE42012
RNA Seq Atlas 101540

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca