InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hif3a

Summary

InnateDB Gene

IDBG-147492.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hif3a

Gene Name

hypoxia inducible factor 3, alpha subunit

Synonyms

bHLHe17; Ipas; MOP7; NEPAS

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004328

Encoded Proteins

IDBP-147496

hypoxia inducible factor 3, alpha subunit

IDBP-264424

hypoxia inducible factor 3, alpha subunit

IDBP-537937

hypoxia inducible factor 3, alpha subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124440:
The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:17031507-17062427

Strand

Reverse strand

Band

Transcripts

ENSMUST00000037762	ENSMUSP00000048248
ENSMUST00000108492	ENSMUSP00000104132
ENSMUST00000139224
ENSMUST00000153833	ENSMUSP00000117728

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction