Mus musculus Gene: Ostm1
Summary
InnateDB Gene IDBG-147636.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ostm1
Gene Name osteopetrosis associated transmembrane protein 1
Synonyms 1200002H13Rik; gl; HSPC019;
Species Mus musculus
Ensembl Gene ENSMUSG00000038280
Encoded Proteins
osteopetrosis associated transmembrane protein 1
osteopetrosis associated transmembrane protein 1
osteopetrosis associated transmembrane protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000081087:
This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:42583822-42702459
Strand Forward strand
Band B2
Transcripts
ENSMUST00000040718 ENSMUSP00000035516
ENSMUST00000105497 ENSMUSP00000101136
ENSMUST00000147899
ENSMUST00000144806 ENSMUSP00000116534
ENSMUST00000154048
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0030316 osteoclast differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Stimuli-sensing channels pathway
Ion channel transport pathway
Transmembrane transport of small molecules pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Stimuli-sensing channels pathway
Ion channel transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.46636 Mm.488327 Mm.490681
RefSeq NM_172416
OMIM
CCDS CCDS23814
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas