InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hoxa10

Summary

InnateDB Gene

IDBG-148041.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hoxa10

Gene Name

homeobox A10

Synonyms

Hox-1.8; Hoxa-10

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000938

Encoded Proteins

IDBP-401269

homeobox A10

IDBP-540984

homeobox A10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of a cluster on chromosome 6 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:52231197-52240854

Strand

Reverse strand

Band

Transcripts

ENSMUST00000121043	ENSMUSP00000112872
ENSMUST00000125581	ENSMUSP00000120276
ENSMUST00000126402
ENSMUST00000142611

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001501	skeletal system development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0007338	single fertilization
GO:0008584	male gonad development
GO:0009952	anterior/posterior pattern specification
GO:0009954	proximal/distal pattern formation
GO:0010468	regulation of gene expression
GO:0030326	embryonic limb morphogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060065	uterus development

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000253293

View Gene Order

ENSBTAG00000040082

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

hdac_classiii_pathway

Signaling events mediated by HDAC Class III

Cross-References

SwissProt

P31310

TrEMBL

UniProt Splice Variant

Entrez Gene

15395

UniGene

Mm.398748 Mm.5

RefSeq

NM_008263 NM_001122950

OMIM

CCDS

CCDS20147 CCDS51775

HPRD

IMGT

MGI ID

MGI:96171

MGI Symbol

Hoxa10

EMBL

BC050839 L08757 L08758 M81659

GenPept

AAA63312 AAA67125 AAD15230 AAH50839

RNA Seq Atlas

15395