Mus musculus Gene: Pglyrp1
Summary
InnateDB Gene IDBG-148760.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pglyrp1
Gene Name peptidoglycan recognition protein 1
Synonyms Pglyrp; PGRP; PGRP-S; Tag7; Tasg7; Tnfsf3l;
Species Mus musculus
Ensembl Gene ENSMUSG00000030413
Encoded Proteins
peptidoglycan recognition protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Pglyrp1 is a peptidoglycan recognition protein and play a role in innate immunity against L. monocytogenes infection by inducing Tnfa.
Pglyrp1 is a member of the Peptidoglycan Recognition Proteins (PGRP) family and recognizes peptidoglycan, a structural component of bacterial cell walls, as a part of innate immune response against infections.
Pglyrp1 binds to Gram-positive bacterial wall and activates a protein-sensing two-component system to induce bacterial death. PLGYRP1-mediated activation results in membrane depolarization and cessation of peptidoglycan, protein, and RNA/DNA synthesis, as well as the production of hydroxyl radicals. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] PGLYRP1 is a secreted innate immunity protein that is expressed in polymorphonuclear leukocytes and is conserved from insects to mammals, it recognizes bacterial peptidoglycan, and functions in antibacterial immunity and inflammation.
[Homo sapiens] PGLYRP1 is a peptidoglycan recognition protein and play a role in innate immunity against L. monocytogenes infection by inducing TNFA. (Demonstrated in murine model)
[Homo sapiens] PGLYRP1 is a member of the Peptidoglycan Recognition Proteins (PGRP) family and recognizes peptidoglycan, a structural component of bacterial cell walls, as a part of innate immune response against infections.
[Homo sapiens] PGLYRP1 binds to Gram-positive bacterial wall and activates a protein-sensing two-component system to induce bacterial death. PLGYRP1-mediated activation results in membrane depolarization and cessation of peptidoglycan, protein, and RNA/DNA synthesis, as well as the production of hydroxyl radicals.
[Homo sapiens] PGLYRP1 binds to bacterially derived peptidoglycan and these complexes constitute potent ligands capable of binding to TREM1 and inducing myeloid cell functions.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000008438:
Gene Information
Type Protein coding
Genomic Location Chromosome 7:18884690-18890438
Strand Forward strand
Band A3
Transcripts
ENSMUST00000032573 ENSMUSP00000032573
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0008270 zinc ion binding
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity
GO:0016019 peptidoglycan receptor activity
GO:0042834 peptidoglycan binding
Biological Process
GO:0002221 pattern recognition receptor signaling pathway
GO:0006915 apoptotic process
GO:0009253 peptidoglycan catabolic process
GO:0016045 detection of bacterium
GO:0032689 negative regulation of interferon-gamma production
GO:0032827 negative regulation of natural killer cell differentiation involved in immune response
GO:0044117 growth of symbiont in host
GO:0045087 innate immune response (InnateDB)
GO:0050728 negative regulation of inflammatory response
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
Toll-like receptor pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.480896
RefSeq NM_009402
OMIM
CCDS CCDS20881
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas