Version 5.4
Mus musculus Gene: Kcnab1
Summary
InnateDB Gene IDBG-149071.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcnab1
Gene Name potassium voltage-gated channel, shaker-related subfamily, beta member 1
Synonyms Akr8a8; Kvbeta1.1; mKv(beta)1
Species Mus musculus
Ensembl Gene ENSMUSG00000027827
Encoded Proteins
IDBP-149073
potassium voltage-gated channel, shaker-related subfamily, beta member 1
IDBP-540399
potassium voltage-gated channel, shaker-related subfamily, beta member 1
IDBP-541379
potassium voltage-gated channel, shaker-related subfamily, beta member 1
IDBP-534304
potassium voltage-gated channel, shaker-related subfamily, beta member 1
IDBP-534279
potassium voltage-gated channel, shaker-related subfamily, beta member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169282:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:65109384-65378223
Strand Forward strand
Band E1
Transcripts
ENSMUST00000049230 ENSMUSP00000047480
ENSMUST00000159525 ENSMUSP00000124311
ENSMUST00000161404 ENSMUSP00000125578
ENSMUST00000161979 ENSMUSP00000125050
ENSMUST00000160136 ENSMUSP00000124058
ENSMUST00000161956
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005249 voltage-gated potassium channel activity
GO:0005515 protein binding
Biological Process
GO:0006813 potassium ion transport
GO:0007611 learning or memory
GO:0071805 potassium ion transmembrane transport
GO:1901016 regulation of potassium ion transmembrane transporter activity
Cellular Component
GO:0005737 cytoplasm
GO:0008076 voltage-gated potassium channel complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000169282
View Gene Order
ENSBTAG00000018465
Not yet available
Pathways
NETPATH
REACTOME
REACT_202800
Potassium Channels pathway
REACT_259290
Neuronal System pathway
REACT_199077
Voltage gated Potassium channels pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75770
Voltage gated Potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
REACT_225032
Neuronal System pathway
REACT_224502
Voltage gated Potassium channels pathway
REACT_212420
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.316402 Mm.444025
RefSeq NM_001289450 NM_010597
OMIM
CCDS CCDS38447
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca