InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RORA

Summary

InnateDB Gene

IDBG-14920.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RORA

Gene Name

RAR-related orphan receptor A

Synonyms

NR1F1; ROR1; ROR2; ROR3; RZR-ALPHA; RZRA

Species

Homo sapiens

Ensembl Gene

ENSG00000069667

Encoded Proteins

IDBP-14922

RAR-related orphan receptor A

IDBP-14924

RAR-related orphan receptor A

IDBP-14926

RAR-related orphan receptor A

IDBP-374270

RAR-related orphan receptor A

IDBP-586746

RAR-related orphan receptor A

IDBP-589575

RAR-related orphan receptor A

IDBP-810828

RAR-related orphan receptor A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22267218

The transcription factor RORA is critical for the development of nuocytes and the mounting of innate type 2 immunity against parasitic worms. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 22267218

[Mus musculus] The transcription factor Rora is critical for the development of nuocytes and the mounting of innate type 2 immunity against parasitic worms.

PMID 26045547

[Mus musculus] Nlrp3 is a novel molecular target for melatonin which requires Rora to blunt the NFkB/ NLRP3 connection during sepsis.

Entrez Gene

Summary

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:60488284-61229319

Strand

Reverse strand

Band

q22.2

Transcripts

ENST00000261523	ENSP00000261523
ENST00000309157	ENSP00000309753
ENST00000335670	ENSP00000335087
ENST00000449337	ENSP00000402971
ENST00000559587
ENST00000551975	ENSP00000449482
ENST00000560004
ENST00000559343	ENSP00000453322
ENST00000558234
ENST00000557822
ENST00000559145
ENST00000561093
ENST00000560300
ENST00000558904	ENSP00000484955

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001222	transcription corepressor binding
GO:0001223	transcription coactivator binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008134	transcription factor binding
GO:0008142	oxysterol binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0098531	direct ligand regulated sequence-specific DNA binding transcription factor activity

Biological Process

GO:0001525	angiogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006805	xenobiotic metabolic process
GO:0006809	nitric oxide biosynthetic process
GO:0007623	circadian rhythm
GO:0008589	regulation of smoothened signaling pathway
GO:0010467	gene expression
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010906	regulation of glucose metabolic process
GO:0019218	regulation of steroid metabolic process
GO:0021702	cerebellar Purkinje cell differentiation
GO:0021930	cerebellar granule cell precursor proliferation
GO:0030522	intracellular receptor signaling pathway
GO:0032922	circadian regulation of gene expression
GO:0036315	cellular response to sterol
GO:0042692	muscle cell differentiation
GO:0042752	regulation of circadian rhythm
GO:0042753	positive regulation of circadian rhythm
GO:0043030	regulation of macrophage activation
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043401	steroid hormone mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045599	negative regulation of fat cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046068	cGMP metabolic process
GO:0050728	negative regulation of inflammatory response
GO:0060850	regulation of transcription involved in cell fate commitment
GO:0070328	triglyceride homeostasis
GO:0071456	cellular response to hypoxia
GO:0072539	T-helper 17 cell differentiation
GO:2000188	regulation of cholesterol homeostasis