Version 5.4
Homo sapiens Gene: RAD18
Summary
InnateDB Gene IDBG-14944.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAD18
Gene Name RAD18 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000070950
Encoded Proteins
IDBP-14948
RAD18 homolog (S. cerevisiae)
IDBP-361199
RAD18 homolog (S. cerevisiae)
IDBP-361222
RAD18 homolog (S. cerevisiae)
IDBP-361226
RAD18 homolog (S. cerevisiae)
IDBP-361228
RAD18 homolog (S. cerevisiae)
IDBP-361231
RAD18 homolog (S. cerevisiae)
IDBP-361232
RAD18 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:8775402-8963773
Strand Reverse strand
Band p25.3
Transcripts
ENST00000264926 ENSP00000264926
ENST00000427329 ENSP00000412054
ENST00000415439 ENSP00000402049
ENST00000429790 ENSP00000393783
ENST00000418463 ENSP00000397852
ENST00000421052 ENSP00000399620
ENST00000413832 ENSP00000412261
ENST00000473069
ENST00000495087
ENST00000469793
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 76 [view]
Protein-Protein 75 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000403 Y-form DNA binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0031593 polyubiquitin binding
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007283 spermatogenesis
GO:0009411 response to UV
GO:0016567 protein ubiquitination
GO:0045910 negative regulation of DNA recombination
Cellular Component
GO:0000785 chromatin
GO:0001741 XY body
GO:0005634 nucleus
GO:0005657 replication fork
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030254
View Gene Order
ENSBTAG00000012142
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.375684 Hs.698087
RefSeq NM_020165
HUGO
OMIM
CCDS CCDS2571
HPRD 09242
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca