Version 5.4
Homo sapiens Gene: DDX56
Summary
InnateDB Gene IDBG-14952.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDX56
Gene Name DEAD (Asp-Glu-Ala-Asp) box helicase 56
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136271
Encoded Proteins
IDBP-14954
DEAD (Asp-Glu-Ala-Asp) box polypeptide 56
IDBP-374183
DEAD (Asp-Glu-Ala-Asp) box polypeptide 56
IDBP-374190
DEAD (Asp-Glu-Ala-Asp) box polypeptide 56
IDBP-374200
DEAD (Asp-Glu-Ala-Asp) box polypeptide 56
IDBP-374201
DEAD (Asp-Glu-Ala-Asp) box polypeptide 56
IDBP-374202
DEAD (Asp-Glu-Ala-Asp) box polypeptide 56
IDBP-374205
DEAD (Asp-Glu-Ala-Asp) box polypeptide 56
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene shows ATPase activity in the presence of polynucleotides and associates with nucleoplasmic 65S preribosomal particles. This gene may be involved in ribosome synthesis, most likely during assembly of the large 60S ribosomal subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:44565417-44575051
Strand Reverse strand
Band p13
Transcripts
ENST00000258772 ENSP00000258772
ENST00000446987 ENSP00000402989
ENST00000421223 ENSP00000392139
ENST00000433257 ENSP00000411456
ENST00000431640 ENSP00000393488
ENST00000448192 ENSP00000390553
ENST00000415758 ENSP00000388310
ENST00000479602
ENST00000485367
ENST00000467318
ENST00000473924
ENST00000479440
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 43 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004004 ATP-dependent RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006364 rRNA processing
GO:0008152 metabolic process
Cellular Component
GO:0005730 nucleolus
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004393
View Gene Order
ENSBTAG00000010602
Not yet available
Cross-References
SwissProt
TrEMBL F8WDT8
UniProt Splice Variant
Entrez Gene 54606
UniGene Hs.654762
RefSeq NM_001257189 NM_019082
HUGO HGNC:18193
OMIM 608023
CCDS CCDS5492 CCDS59053
HPRD 12154
IMGT
EMBL AC004938
GenPept
RNA Seq Atlas 54606

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca