InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fhl2

Summary

InnateDB Gene

IDBG-149554.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fhl2

Gene Name

four and a half LIM domains 2

Synonyms

FHL-2; SLIM-3; SLIM3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000008136

Encoded Proteins

IDBP-149556

four and a half LIM domains 2

IDBP-788828

four and a half LIM domains 2

IDBP-788829

four and a half LIM domains 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the four-and-a-half-LIM-only protein family. The encoded protein functions as a regulator in numerous signaling pathways and cellular processes in development and cellular differentiation, including development and maintenance of the cardiovascular system and striated muscles. This gene also plays a role in bone formation and regulates and bone mineral content and bone mineral density. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:43123074-43196984

Strand

Reverse strand

Band

Transcripts

ENSMUST00000008280	ENSMUSP00000008280
ENSMUST00000185893	ENSMUSP00000141170
ENSMUST00000187357	ENSMUSP00000140420

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	68 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0042802	identical protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001649	osteoblast differentiation
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0009725	response to hormone
GO:0043066	negative regulation of apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0055014	atrial cardiac muscle cell development
GO:0055015	ventricular cardiac muscle cell development
GO:0060347	heart trabecula formation