Version 5.4
Homo sapiens Gene: PITPNA
Summary
InnateDB Gene IDBG-14960.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PITPNA
Gene Name phosphatidylinositol transfer protein, alpha
Synonyms HEL-S-36; PI-TPalpha; PITPN; VIB1A
Species Homo sapiens
Ensembl Gene ENSG00000174238
Encoded Proteins
IDBP-14962
phosphatidylinositol transfer protein, alpha
IDBP-600860
phosphatidylinositol transfer protein, alpha
IDBP-759568
IDBP-763997
IDBP-762917
IDBP-758197
IDBP-761742
IDBP-762755
IDBP-758102
IDBP-761982
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) by phosphoinositide-3-kinase.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:1517718-1562816
Strand Reverse strand
Band p13.3
Transcripts
ENST00000313486 ENSP00000316809
ENST00000539476 ENSP00000441869
ENST00000576761 ENSP00000461801
ENST00000575895 ENSP00000461140
ENST00000576010 ENSP00000460008
ENST00000573056 ENSP00000461539
ENST00000575288 ENSP00000461011
ENST00000576722 ENSP00000460983
ENST00000572004
ENST00000573231 ENSP00000460771
ENST00000574991 ENSP00000461245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008289 lipid binding
GO:0008525 phosphatidylcholine transporter activity
GO:0008526 phosphatidylinositol transporter activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006810 transport
GO:0007411 axon guidance
GO:0007601 visual perception
GO:0015914 phospholipid transport
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017781
View Gene Order
ENSBTAG00000011480
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_22228
Role of second messengers in netrin-1 signaling pathway
REACT_22237
Netrin-1 signaling pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
INOH
PID NCI
netrin_pathway
Netrin-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.429819
RefSeq NM_006224
HUGO
OMIM
CCDS CCDS45563
HPRD 02548
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca