Homo sapiens Gene: PITPNA
Summary
InnateDB Gene IDBG-14960.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PITPNA
Gene Name phosphatidylinositol transfer protein, alpha
Synonyms HEL-S-36; PI-TPalpha; PITPN; VIB1A;
Species Homo sapiens
Ensembl Gene ENSG00000174238
Encoded Proteins
phosphatidylinositol transfer protein, alpha
phosphatidylinositol transfer protein, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) by phosphoinositide-3-kinase.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:1517718-1562816
Strand Reverse strand
Band p13.3
Transcripts
ENST00000313486 ENSP00000316809
ENST00000539476 ENSP00000441869
ENST00000576761 ENSP00000461801
ENST00000575895 ENSP00000461140
ENST00000576010 ENSP00000460008
ENST00000573056 ENSP00000461539
ENST00000575288 ENSP00000461011
ENST00000576722 ENSP00000460983
ENST00000572004
ENST00000573231 ENSP00000460771
ENST00000574991 ENSP00000461245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008289 lipid binding
GO:0008525 phosphatidylcholine transporter activity
GO:0008526 phosphatidylinositol transporter activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006810 transport
GO:0007411 axon guidance
GO:0007601 visual perception
GO:0015914 phospholipid transport
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
EGFR1 pathway
REACTOME
Developmental Biology pathway
Axon guidance pathway
Netrin-1 signaling pathway
Role of second messengers in netrin-1 signaling pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Netrin-mediated signaling events
Cross-References
SwissProt Q00169
TrEMBL B4E1U1 F5GWE5 I3L2X8 I3L3W1 I3L459 I3L471 I3L4C0 I3L4U7 I3NI10 V9HWC5
UniProt Splice Variant
Entrez Gene 5306
UniGene Hs.429819
RefSeq NM_006224
HUGO HGNC:9001
OMIM 600174
CCDS CCDS45563
HPRD
IMGT
EMBL AC100748 AK303986 BC045108 BC082976 D30036 EU794647 M73704
GenPept AAA36441 AAH45108 AAH82976 ACJ13701 BAA06276 BAG64903
RNA Seq Atlas 5306