InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Shox2

Summary

InnateDB Gene

IDBG-149928.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Shox2

Gene Name

short stature homeobox 2

Synonyms

6330543G17Rik; OG12; Og12x; Prx3; SHOT

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027833

Encoded Proteins

IDBP-149930

short stature homeobox 2

IDBP-538711

short stature homeobox 2

IDBP-534807

short stature homeobox 2

IDBP-534689

short stature homeobox 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168779:
This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:66971727-66981771

Strand

Reverse strand

Band

Transcripts

ENSMUST00000029422	ENSMUSP00000029422
ENSMUST00000162098	ENSMUSP00000123838
ENSMUST00000162439	ENSMUSP00000124924
ENSMUST00000162060	ENSMUSP00000125031

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001649	osteoblast differentiation
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002062	chondrocyte differentiation
GO:0002063	chondrocyte development
GO:0003170	heart valve development
GO:0003209	cardiac atrium morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0030326	embryonic limb morphogenesis
GO:0032330	regulation of chondrocyte differentiation
GO:0035115	embryonic forelimb morphogenesis
GO:0045880	positive regulation of smoothened signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048557	embryonic digestive tract morphogenesis
GO:0048598	embryonic morphogenesis
GO:0048743	positive regulation of skeletal muscle fiber development
GO:0050772	positive regulation of axonogenesis
GO:0060272	embryonic skeletal joint morphogenesis
GO:0060351	cartilage development involved in endochondral bone morphogenesis
GO:0060415	muscle tissue morphogenesis
GO:2000172	regulation of branching morphogenesis of a nerve

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000168779

View Gene Order

ENSBTAG00000005230

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.39093

RefSeq

NM_013665 XM_006501214 XM_006501218

OMIM

CCDS

CCDS17393

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas