Version 5.4
Mus musculus Gene: Smc4
Summary
InnateDB Gene IDBG-151131.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smc4
Gene Name structural maintenance of chromosomes 4
Synonyms 2500002A22Rik; C79747; SMC-4; Smc4l1
Species Mus musculus
Ensembl Gene ENSMUSG00000034349
Encoded Proteins
IDBP-151133
structural maintenance of chromosomes 4
IDBP-265880
structural maintenance of chromosomes 4
IDBP-531926
structural maintenance of chromosomes 4
IDBP-532466
structural maintenance of chromosomes 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113810:
Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:69004738-69034623
Strand Forward strand
Band E1
Transcripts
ENSMUST00000042901 ENSMUSP00000047872
ENSMUST00000107803 ENSMUSP00000103433
ENSMUST00000136502 ENSMUSP00000115033
ENSMUST00000148385 ENSMUSP00000123350
ENSMUST00000128134
ENSMUST00000124983
ENSMUST00000156354
ENSMUST00000149174
ENSMUST00000128118
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007076 mitotic chromosome condensation
GO:0010032 meiotic chromosome condensation
GO:0045132 meiotic chromosome segregation
GO:0051276 chromosome organization
GO:0051383 kinetochore organization
Cellular Component
GO:0000796 condensin complex
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000113810
View Gene Order
ENSBTAG00000005862
Not yet available
Pathways
NETPATH
REACTOME
REACT_249770
Cell Cycle, Mitotic pathway
REACT_188804
Cell Cycle pathway
REACT_241408
M Phase pathway
REACT_196580
Condensation of Prophase Chromosomes pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_196632
Condensation of Prometaphase Chromosomes pathway
REACT_250557
Mitotic Prophase pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150260
Condensation of Prometaphase Chromosomes pathway
REACT_682
Mitotic Prometaphase pathway
REACT_172744
Condensation of Prophase Chromosomes pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_765
Mitotic Prophase pathway
REACT_152
Cell Cycle, Mitotic pathway
KEGG
INOH
PID NCI
aurora_b_pathway
Aurora B signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.206841 Mm.399261 Mm.404952 Mm.458564
RefSeq NM_133786 XM_006502045 XM_006502046 XM_006502047 XM_006502048
OMIM
CCDS CCDS17401
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca