Version 5.4
Mus musculus Gene: Herc3
Summary
InnateDB Gene IDBG-151863.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Herc3
Gene Name hect domain and RLD 3
Synonyms 5730409F18Rik; AI646603; mKIAA0032
Species Mus musculus
Ensembl Gene ENSMUSG00000029804
Encoded Proteins
IDBP-151865
hect domain and RLD 3
IDBP-151867
hect domain and RLD 3
IDBP-537779
hect domain and RLD 3
IDBP-539300
hect domain and RLD 3
IDBP-540132
hect domain and RLD 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138641:
This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:58831465-58920398
Strand Forward strand
Band B3
Transcripts
ENSMUST00000031823 ENSMUSP00000031823
ENSMUST00000041401 ENSMUSP00000040025
ENSMUST00000141600 ENSMUSP00000122762
ENSMUST00000122981 ENSMUSP00000119115
ENSMUST00000126292 ENSMUSP00000122401
ENSMUST00000154290
ENSMUST00000122908
ENSMUST00000131132
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0016874 ligase activity
Biological Process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138641
View Gene Order
ENSBTAG00000010120
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.487814
RefSeq NM_028705 XM_006506695 XM_006506696 XM_006506697 XM_006506698 XM_006506699 XM_006506700
OMIM
CCDS CCDS20196
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca