InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mpp5

Summary

InnateDB Gene

IDBG-151957.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mpp5

Gene Name

membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)

Synonyms

3830420B02Rik; AI255216; AI644496; Pals1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021112

Encoded Proteins

IDBP-151961

membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072415:
This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:78748947-78840711

Strand

Forward strand

Band

Transcripts

ENSMUST00000082024

ENSMUSP00000080683

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004385	guanylate kinase activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding

Biological Process

GO:0002011	morphogenesis of an epithelial sheet
GO:0007009	plasma membrane organization
GO:0032287	peripheral nervous system myelin maintenance
GO:0032288	myelin assembly
GO:0035750	protein localization to myelin sheath abaxonal region
GO:0046939	nucleotide phosphorylation
GO:0090002	establishment of protein localization to plasma membrane

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0012505	endomembrane system
GO:0016021	integral component of membrane
GO:0035749	myelin sheath adaxonal region
GO:0043219	lateral loop
GO:0043220	Schmidt-Lanterman incisure
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000072415

View Gene Order

ENSBTAG00000011767

Not yet available

Pathways

NETPATH

REACTOME

REACT_248094

Cell-cell junction organization pathway

REACT_241978

Cell junction organization pathway

REACT_236746

Tight junction interactions pathway

REACT_223082

Cell-Cell communication pathway

KEGG

mmu04530

Tight junction pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_19373

Tight junction interactions pathway

REACT_111155

Cell-Cell communication pathway

REACT_20676

Cell junction organization pathway

REACT_19331

Cell-cell junction organization pathway

KEGG

hsa04530

Tight junction pathway

INOH

PID NCI

Cross-References

SwissProt

Q9JLB2

TrEMBL

B2RRY4

UniProt Splice Variant

Entrez Gene

56217

UniGene

Mm.400728 Mm.425777 Mm.470774

RefSeq

NM_019579 XM_006516097 XM_006516098 XM_006516099

OMIM

CCDS

CCDS26001

HPRD

IMGT

MGI ID

MGI:1927339

MGI Symbol

Mpp5

EMBL

AF199008 BC138624 CH466590

GenPept

AAF63789 AAI38625 EDL02623

RNA Seq Atlas

56217