Mus musculus Gene: Mpp5
Summary
InnateDB Gene IDBG-151957.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mpp5
Gene Name membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Synonyms 3830420B02Rik; AI255216; AI644496; Pals1;
Species Mus musculus
Ensembl Gene ENSMUSG00000021112
Encoded Proteins
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072415:
This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:78748947-78840711
Strand Forward strand
Band C3
Transcripts
ENSMUST00000082024 ENSMUSP00000080683
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004385 guanylate kinase activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0002011 morphogenesis of an epithelial sheet
GO:0007009 plasma membrane organization
GO:0032287 peripheral nervous system myelin maintenance
GO:0032288 myelin assembly
GO:0035750 protein localization to myelin sheath abaxonal region
GO:0046939 nucleotide phosphorylation
GO:0090002 establishment of protein localization to plasma membrane
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0012505 endomembrane system
GO:0016021 integral component of membrane
GO:0035749 myelin sheath adaxonal region
GO:0043219 lateral loop
GO:0043220 Schmidt-Lanterman incisure
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cell-cell junction organization pathway
Cell junction organization pathway
Tight junction interactions pathway
Cell-Cell communication pathway
KEGG
Tight junction pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Tight junction interactions pathway
Cell-Cell communication pathway
Cell junction organization pathway
Cell-cell junction organization pathway
KEGG
Tight junction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9JLB2
TrEMBL B2RRY4
UniProt Splice Variant
Entrez Gene 56217
UniGene Mm.400728 Mm.425777 Mm.470774
RefSeq NM_019579 XM_006516097 XM_006516098 XM_006516099
OMIM
CCDS CCDS26001
HPRD
IMGT
MGI ID MGI:1927339
MGI Symbol Mpp5
EMBL AF199008 BC138624 CH466590
GenPept AAF63789 AAI38625 EDL02623
RNA Seq Atlas 56217