InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rgs3

Summary

InnateDB Gene

IDBG-153650.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgs3

Gene Name

regulator of G-protein signaling 3

Synonyms

4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3; RGS3S

Species

Mus musculus

Ensembl Gene

ENSMUSG00000059810

Encoded Proteins

IDBP-153652

regulator of G-protein signaling 3

IDBP-153654

regulator of G-protein signaling 3

IDBP-153656

regulator of G-protein signaling 3

IDBP-266678

regulator of G-protein signaling 3

IDBP-266680

regulator of G-protein signaling 3

IDBP-539425

regulator of G-protein signaling 3

IDBP-542208

regulator of G-protein signaling 3

IDBP-539780

regulator of G-protein signaling 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138835:
This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:62559847-62704001

Strand

Forward strand

Band

Transcripts

ENSMUST00000065870	ENSMUSP00000065447
ENSMUST00000098031	ENSMUSP00000095639
ENSMUST00000084521	ENSMUSP00000081569
ENSMUST00000107424	ENSMUSP00000103047
ENSMUST00000107420	ENSMUSP00000103043
ENSMUST00000146083
ENSMUST00000143042
ENSMUST00000154071
ENSMUST00000142684
ENSMUST00000144489
ENSMUST00000127254
ENSMUST00000126338	ENSMUSP00000116041
ENSMUST00000124082	ENSMUSP00000115192
ENSMUST00000138674
ENSMUST00000125369
ENSMUST00000142565
ENSMUST00000153875	ENSMUSP00000123310

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000138835

View Gene Order

ENSBTAG00000004499

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04360

Axon guidance pathway

INOH

INOH website

GPCR signaling pathway

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04360

Axon guidance pathway

INOH

INOH website

GPCR signaling pathway

PID NCI

ephrinbrevpathway

Ephrin B reverse signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.286753 Mm.350679 Mm.413144

RefSeq

NM_001081650 NM_019492 NM_134257 XM_006538054 XM_006538055 XM_006538056 XM_006538057 XM_006538058 XM_006538059 XM_006538060 XM_006538061 XM_006538062 XM_006538064 XM_006538065 XM_006538066 XM_006538067 XM_006538069 XM_006538070

OMIM

CCDS

CCDS18246 CCDS38776 CCDS51202

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas