InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tfrc

Summary

InnateDB Gene

IDBG-154429.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tfrc

Gene Name

transferrin receptor

Synonyms

2610028K12Rik; AI195355; AI426448; AU015758; CD71; E430033M20Rik; Mtvr-1; Mtvr1; p90; TFR; TFR1; TR; Trfr

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022797

Encoded Proteins

IDBP-154431

transferrin receptor

IDBP-401280

transferrin receptor

IDBP-536998

transferrin receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:32608920-32632794

Strand

Forward strand

Band

Transcripts

ENSMUST00000023486	ENSMUSP00000023486
ENSMUST00000120680	ENSMUSP00000113028
ENSMUST00000124243	ENSMUSP00000123423
ENSMUST00000137901
ENSMUST00000155929
ENSMUST00000128285

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0004998	transferrin receptor activity
GO:0005381	iron ion transmembrane transporter activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006508	proteolysis
GO:0006879	cellular iron ion homeostasis
GO:0006898	receptor-mediated endocytosis
GO:0030316	osteoclast differentiation
GO:0034755	iron ion transmembrane transport
GO:0045780	positive regulation of bone resorption
GO:0097286	iron ion import

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0042470	melanosome
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle