Version 5.4
Mus musculus Gene: Plrg1
Summary
InnateDB Gene IDBG-154656.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plrg1
Gene Name pleiotropic regulator 1, PRL1 homolog (Arabidopsis)
Synonyms AA958940; C80566; Tango4
Species Mus musculus
Ensembl Gene ENSMUSG00000027998
Encoded Proteins
IDBP-154658
pleiotropic regulator 1, PRL1 homolog (Arabidopsis)
IDBP-401273
pleiotropic regulator 1, PRL1 homolog (Arabidopsis)
IDBP-542557
pleiotropic regulator 1, PRL1 homolog (Arabidopsis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171566:
This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:83055522-83072355
Strand Forward strand
Band E3
Transcripts
ENSMUST00000029628 ENSMUSP00000029628
ENSMUST00000122128 ENSMUSP00000113614
ENSMUST00000150268 ENSMUSP00000114968
ENSMUST00000151915
ENSMUST00000135813
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0034504 protein localization to nucleus
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171566
View Gene Order
ENSBTAG00000007234
Not yet available
Pathways
NETPATH
REACTOME
REACT_249110
mRNA Splicing pathway
REACT_233572
Gene Expression pathway
REACT_260226
mRNA Splicing - Major Pathway pathway
REACT_233950
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
mmu03040
Spliceosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
REACT_205948
mRNA Splicing - Major Pathway pathway
REACT_206725
mRNA Splicing pathway
REACT_226022
Gene Expression pathway
REACT_226302
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F8WI31
UniProt Splice Variant
Entrez Gene 53317
UniGene Mm.286349
RefSeq NM_016784
OMIM
CCDS CCDS17433
HPRD
IMGT
MGI ID MGI:1858197
MGI Symbol Plrg1
EMBL AC138394
GenPept
RNA Seq Atlas 53317

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca