Version 5.4
Mus musculus Gene: Sf3b1
Summary
InnateDB Gene IDBG-154934.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sf3b1
Gene Name splicing factor 3b, subunit 1
Synonyms 155kDa; 2810001M05Rik; AA409119; Prp10; SAP155; SF3b155; TA-8; Targ4
Species Mus musculus
Ensembl Gene ENSMUSG00000025982
Encoded Proteins
IDBP-154936
splicing factor 3b, subunit 1
IDBP-790234
splicing factor 3b, subunit 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115524:
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron\'s branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:54985169-55027481
Strand Reverse strand
Band C1.2
Transcripts
ENSMUST00000027127 ENSMUSP00000027127
ENSMUST00000190175
ENSMUST00000185429
ENSMUST00000187500
ENSMUST00000188859
ENSMUST00000191303 ENSMUSP00000139469
ENSMUST00000189051
ENSMUST00000188419
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 113 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 113 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005488 binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0009952 anterior/posterior pattern specification
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005689 U12-type spliceosomal complex
GO:0043231 intracellular membrane-bounded organelle
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115524
View Gene Order
ENSBTAG00000008915
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03040
Spliceosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_1753
mRNA Splicing - Minor Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G5E866 Q3US00 Q8C2Y9
UniProt Splice Variant
Entrez Gene 81898
UniGene Mm.279736 Mm.406476 Mm.409874 Mm.412798
RefSeq NM_031179
OMIM
CCDS CCDS35567
HPRD
IMGT
MGI ID MGI:1932339
MGI Symbol Sf3b1
EMBL AC108391 AC166111 AK087700 AK140982 CH466548
GenPept BAC39971 BAE24537 EDL00014
RNA Seq Atlas 81898

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca