Version 5.4
Mus musculus Gene: Whrn
Summary
InnateDB Gene IDBG-154965.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Whrn
Gene Name whirlin
Synonyms 1110035G07Rik; AW122018; AW742671; C430046P22Rik; Dfnb31; wi
Species Mus musculus
Ensembl Gene ENSMUSG00000039137
Encoded Proteins
IDBP-154967
whirlin
IDBP-154969
whirlin
IDBP-154971
whirlin
IDBP-154973
whirlin
IDBP-154975
whirlin
IDBP-154979
whirlin
IDBP-266763
whirlin
IDBP-400747
whirlin
IDBP-540176
whirlin
IDBP-535713
whirlin
IDBP-534563
whirlin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein required for elongation and actin polymerization in the hair cell stereocilia. The encoded protein is localized to the cytoplasm and co-localizes with the growing end of actin filaments. Mutations in this gene have been linked to deafness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:63414910-63495991
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000084510 ENSMUSP00000081557
ENSMUST00000063650 ENSMUSP00000069664
ENSMUST00000095038 ENSMUSP00000092648
ENSMUST00000095037 ENSMUSP00000092647
ENSMUST00000102867 ENSMUSP00000099931
ENSMUST00000063672 ENSMUSP00000065838
ENSMUST00000107393 ENSMUSP00000103016
ENSMUST00000119294 ENSMUSP00000114030
ENSMUST00000155058
ENSMUST00000145133
ENSMUST00000124016
ENSMUST00000145630 ENSMUSP00000116387
ENSMUST00000148957
ENSMUST00000153307
ENSMUST00000144965 ENSMUSP00000121944
ENSMUST00000133425 ENSMUSP00000119280
ENSMUST00000140720
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001895 retina homeostasis
GO:0007605 sensory perception of sound
GO:0050953 sensory perception of light stimulus
GO:0060122 inner ear receptor stereocilium organization
Cellular Component
GO:0002142 stereocilia ankle link complex
GO:0005737 cytoplasm
GO:0005884 actin filament
GO:0005929 cilium
GO:0030426 growth cone
GO:0032420 stereocilium
GO:0032421 stereocilium bundle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000095397
View Gene Order
ENSBTAG00000010107
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.300397 Mm.449056
RefSeq NM_001008791 NM_001008792 NM_001008793 NM_001008794 NM_001008795 NM_001008796 NM_001008797 NM_028640 XM_006538309
OMIM
CCDS CCDS18255 CCDS18256 CCDS18257 CCDS38778
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca