InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kank1

Summary

InnateDB Gene

IDBG-155251.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kank1

Gene Name

KN motif and ankyrin repeat domains 1

Synonyms

A930031B09Rik; Ankrd15; AU015049; AW121052; D330024H06Rik; mKIAA0172

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032702

Encoded Proteins

IDBP-155253

KN motif and ankyrin repeat domains 1

IDBP-535332

KN motif and ankyrin repeat domains 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107104:
The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseuodgene has been identified on chromosome 20. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:25236975-25434496

Strand

Forward strand

Band

Transcripts

ENSMUST00000049400	ENSMUSP00000042177
ENSMUST00000137260
ENSMUST00000146647	ENSMUSP00000116660
ENSMUST00000155788

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008013	beta-catenin binding

Biological Process

GO:0010977	negative regulation of neuron projection development
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030336	negative regulation of cell migration
GO:0030837	negative regulation of actin filament polymerization
GO:0035024	negative regulation of Rho protein signal transduction
GO:0035413	positive regulation of catenin import into nucleus
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0090303	positive regulation of wound healing
GO:1900025	negative regulation of substrate adhesion-dependent cell spreading
GO:1900028	negative regulation of ruffle assembly
GO:2000114	regulation of establishment of cell polarity
GO:2000393	negative regulation of lamellipodium morphogenesis

Cellular Component

GO:0032587

ruffle membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000107104

View Gene Order

ENSBTAG00000010976

Not yet available

Cross-References

SwissProt

TrEMBL

E9Q238 E9Q944 Q8BRZ8 Q8BUK3

UniProt Splice Variant

Entrez Gene

107351

UniGene

Mm.260722

RefSeq

NM_181404 XM_006526584 XM_006526585 XM_006526586 XM_006526587 XM_006526588 XM_006526589 XM_006526590

OMIM

CCDS

CCDS37944

HPRD

IMGT

MGI ID

MGI:2147707

MGI Symbol

Kank1

EMBL

AC126944 AC132319 AK041011 AK084638

GenPept

BAC30778 BAC39237

RNA Seq Atlas

107351