Homo sapiens Gene: PHOX2B
InnateDB Gene IDBG-15536.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHOX2B
Gene Name paired-like homeobox 2b
Synonyms NBLST2; NBPhox; PMX2B;
Species Homo sapiens
Ensembl Gene ENSG00000109132
Encoded Proteins
paired-like homeobox 2b
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:41744082-41748970
Strand Reverse strand
Band p13
ENST00000226382 ENSP00000226382
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0001764 neuron migration
GO:0002087 regulation of respiratory gaseous exchange by neurological system process
GO:0003357 noradrenergic neuron differentiation
GO:0003358 noradrenergic neuron development
GO:0003360 brainstem development
GO:0006351 transcription, DNA-templated
GO:0008285 negative regulation of cell proliferation
GO:0010001 glial cell differentiation
GO:0010468 regulation of gene expression
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0021533 cell differentiation in hindbrain
GO:0021723 medullary reticular formation development
GO:0021934 hindbrain tangential cell migration
GO:0030182 neuron differentiation
GO:0035914 skeletal muscle cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048468 cell development
GO:0048483 autonomic nervous system development
GO:0048484 enteric nervous system development
GO:0048485 sympathetic nervous system development
GO:0048486 parasympathetic nervous system development
GO:0048839 inner ear development
GO:0048894 efferent axon development in a lateral line nerve
GO:0060541 respiratory system development
GO:0061452 retrotrapezoid nucleus neuron differentiation
GO:0061549 sympathetic ganglion development
GO:0071157 negative regulation of cell cycle arrest
GO:0071542 dopaminergic neuron differentiation
GO:0071773 cellular response to BMP stimulus
GO:1901166 neural crest cell migration involved in autonomic nervous system development
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
Mus musculus
Bos taurus
Gene ID
Gene Order
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
SwissProt Q99453
UniProt Splice Variant
Entrez Gene 8929
UniGene Hs.87202
RefSeq NM_003924
OMIM 603851
EMBL AB015671 AF117979 BC017199 D82344
GenPept AAD26698 AAH17199 BAA11555 BAA82670
RNA Seq Atlas 8929