Version 5.4
Homo sapiens Gene: PHOX2B
Summary
InnateDB Gene IDBG-15536.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHOX2B
Gene Name paired-like homeobox 2b
Synonyms NBLST2; NBPhox; PMX2B
Species Homo sapiens
Ensembl Gene ENSG00000109132
Encoded Proteins
IDBP-15540
paired-like homeobox 2b
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:41744082-41748970
Strand Reverse strand
Band p13
Transcripts
ENST00000226382 ENSP00000226382
ENST00000510424
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0001764 neuron migration
GO:0002087 regulation of respiratory gaseous exchange by neurological system process
GO:0003357 noradrenergic neuron differentiation
GO:0003358 noradrenergic neuron development
GO:0003360 brainstem development
GO:0006351 transcription, DNA-templated
GO:0008285 negative regulation of cell proliferation
GO:0010001 glial cell differentiation
GO:0010468 regulation of gene expression
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0021533 cell differentiation in hindbrain
GO:0021723 medullary reticular formation development
GO:0021934 hindbrain tangential cell migration
GO:0030182 neuron differentiation
GO:0035914 skeletal muscle cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048468 cell development
GO:0048483 autonomic nervous system development
GO:0048484 enteric nervous system development
GO:0048485 sympathetic nervous system development
GO:0048486 parasympathetic nervous system development
GO:0048839 inner ear development
GO:0048894 efferent axon development in a lateral line nerve
GO:0060541 respiratory system development
GO:0061452 retrotrapezoid nucleus neuron differentiation
GO:0061549 sympathetic ganglion development
GO:0071157 negative regulation of cell cycle arrest
GO:0071542 dopaminergic neuron differentiation
GO:0071773 cellular response to BMP stimulus
GO:1901166 neural crest cell migration involved in autonomic nervous system development
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000012520
View Gene Order
ENSBTAG00000044166
Not yet available
Cross-References
SwissProt Q99453
TrEMBL
UniProt Splice Variant
Entrez Gene 8929
UniGene Hs.87202
RefSeq NM_003924
HUGO HGNC:9143
OMIM 603851
CCDS CCDS3463
HPRD
IMGT
EMBL AB015671 AF117979 BC017199 D82344
GenPept AAD26698 AAH17199 BAA11555 BAA82670
RNA Seq Atlas 8929

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca