InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kdm3a

Summary

InnateDB Gene

IDBG-155780.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kdm3a

Gene Name

lysine (K)-specific demethylase 3A

Synonyms

1700105C21Rik; C230043E16Rik; JHDM2a; Jmjd1; Jmjd1a; KDM2A; TGSA; Tsga

Species

Mus musculus

Ensembl Gene

ENSMUSG00000053470

Encoded Proteins

IDBP-155782

lysine (K)-specific demethylase 3A

IDBP-619801

lysine (K)-specific demethylase 3A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115548:
This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:71588974-71632905

Strand

Reverse strand

Band

Transcripts

ENSMUST00000065509	ENSMUSP00000065716
ENSMUST00000167220	ENSMUSP00000128789

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0050681	androgen receptor binding
GO:0051213	dioxygenase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007283	spermatogenesis
GO:0007290	spermatid nucleus elongation
GO:0009755	hormone-mediated signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0033169	histone H3-K9 demethylation
GO:0036123	histone H3-K9 dimethylation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046293	formaldehyde biosynthetic process
GO:0051573	negative regulation of histone H3-K9 methylation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000115548

View Gene Order

ENSBTAG00000013580

Not yet available

Pathways

NETPATH

REACTOME

REACT_218274

Chromatin organization pathway

REACT_256030

HDMs demethylate histones pathway

REACT_202766

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

REACT_228178

HDMs demethylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

ar_pathway

Coregulation of Androgen receptor activity

Cross-References

SwissProt

Q6PCM1

TrEMBL

A0JLP7

UniProt Splice Variant

Entrez Gene

104263

UniGene

Mm.260479 Mm.475195

RefSeq

NM_173001 XM_006505264 XM_006505265 XM_006505266 XM_006505268 NM_001038695

OMIM

CCDS

CCDS20233

HPRD

IMGT

MGI ID

MGI:98847

MGI Symbol

Kdm3a

EMBL

AK129204 AK144825 AK166797 BC005725 BC026605 BC031158 BC031200 BC059264 DQ323991

GenPept

AAH05725 AAH26605 AAH31158 AAH31200 AAH59264 ABC54567 BAC98014 BAE26085 BAE39025

RNA Seq Atlas

104263