Mus musculus Gene: Umps
Summary
InnateDB Gene IDBG-155909.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Umps
Gene Name uridine monophosphate synthetase
Synonyms 1700095D23Rik; AA408257; AL033308; BB164745;
Species Mus musculus
Ensembl Gene ENSMUSG00000022814
Encoded Proteins
uridine monophosphate synthetase
uridine monophosphate synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114491:
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
This gene encodes a uridine 5\'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5\'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5\'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:33954782-33967038
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000023510 ENSMUSP00000023510
ENSMUST00000131990 ENSMUSP00000119423
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004588 orotate phosphoribosyltransferase activity
GO:0004590 orotidine-5'-phosphate decarboxylase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006222 UMP biosynthetic process
GO:0007565 female pregnancy
GO:0007595 lactation
GO:0008152 metabolic process
GO:0009116 nucleoside metabolic process
GO:0035690 cellular response to drug
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Pyrimidine biosynthesis pathway
Pyrimidine metabolism pathway
Metabolism pathway
Metabolism of nucleotides pathway
KEGG
Pyrimidine metabolism pathway
Drug metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Pyrimidine metabolism pathway
Metabolism of nucleotides pathway
Metabolism pathway
Pyrimidine biosynthesis pathway
Pyrimidine metabolism pathway
Metabolism of nucleotides pathway
Metabolism pathway
Pyrimidine biosynthesis pathway
KEGG
Pyrimidine metabolism pathway
Drug metabolism pathway
INOH
Pentose phosphate cycle pathway
Pyrimidine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.13145 Mm.467819
RefSeq NM_009471
OMIM
CCDS CCDS28136
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas