InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Umps

Summary

InnateDB Gene

IDBG-155909.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Umps

Gene Name

uridine monophosphate synthetase

Synonyms

1700095D23Rik; AA408257; AL033308; BB164745

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022814

Encoded Proteins

IDBP-155911

uridine monophosphate synthetase

IDBP-532152

uridine monophosphate synthetase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114491:
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
This gene encodes a uridine 5\'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5\'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5\'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:33954782-33967038

Strand

Reverse strand

Band

Transcripts

ENSMUST00000023510	ENSMUSP00000023510
ENSMUST00000131990	ENSMUSP00000119423

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004588	orotate phosphoribosyltransferase activity
GO:0004590	orotidine-5'-phosphate decarboxylase activity

Biological Process

GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
GO:0006222	UMP biosynthetic process
GO:0007565	female pregnancy
GO:0007595	lactation
GO:0008152	metabolic process
GO:0009116	nucleoside metabolic process
GO:0035690	cellular response to drug
GO:0044205	'de novo' UMP biosynthetic process