Mus musculus Gene: Efemp1
Summary
InnateDB Gene IDBG-156386.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Efemp1
Gene Name epidermal growth factor-containing fibulin-like extracellular matrix protein 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020467
Encoded Proteins
epidermal growth factor-containing fibulin-like extracellular matrix protein 1
epidermal growth factor-containing fibulin-like extracellular matrix protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115380:
This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:28853204-28926743
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000020759 ENSMUSP00000020759
ENSMUST00000124103
ENSMUST00000139713 ENSMUSP00000114757
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0032331 negative regulation of chondrocyte differentiation
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Elastic fibre formation pathway
Molecules associated with elastic fibres pathway
Extracellular matrix organization pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Elastic fibre formation pathway
Extracellular matrix organization pathway
Molecules associated with elastic fibres pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.44176
RefSeq NM_146015 XM_006514659 XM_006514660 XM_006514661 XM_006514662
OMIM
CCDS CCDS48761
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas