Mus musculus Gene: Ddx46
Summary
InnateDB Gene IDBG-156566.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ddx46
Gene Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000021500
Encoded Proteins
DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145833:
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:55635027-55681256
Strand Forward strand
Band B1
Transcripts
ENSMUST00000099479 ENSMUSP00000097078
ENSMUST00000172272 ENSMUSP00000133245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006397 mRNA processing
GO:0008152 metabolic process
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0015030 Cajal body
GO:0016607 nuclear speck
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F8WHR6 Q3UUW9 Q9CVD6
UniProt Splice Variant
Entrez Gene 212880
UniGene Mm.202725 Mm.392552 Mm.474698
RefSeq XM_006517203 NM_145975 NM_001282055 XM_006517202
OMIM
CCDS CCDS70464
HPRD
IMGT
MGI ID MGI:1920895
MGI Symbol Ddx46
EMBL AC126408 AK008639 AK137835
GenPept BAB25800 BAE23504
RNA Seq Atlas 212880