Version 5.4
Mus musculus Gene: Ccdc88a
Summary
InnateDB Gene IDBG-157020.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccdc88a
Gene Name coiled coil domain containing 88A
Synonyms A430106J12Rik; AI848406; Ape; C130096N06Rik; C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1
Species Mus musculus
Ensembl Gene ENSMUSG00000032740
Encoded Proteins
IDBP-157022
coiled coil domain containing 88A
IDBP-262303
coiled coil domain containing 88A
IDBP-534783
coiled coil domain containing 88A
IDBP-536332
coiled coil domain containing 88A
IDBP-539843
coiled coil domain containing 88A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21209316
Ccdc88a, an activator of Gnai3, plays a key role in regulating autophagy; the dynamic interplay between Gnai3, Gpsm1 and Ccdc88a determines whether autophagy is promoted or inhibited. When stimulated by growth factors, Ccdc88a disrupts the Gnai3::Gpsm1 complex, subsequently enhancing anti-autophagy signaling pathways and inhibits autophagy by activating Gnai3.
InnateDB Annotation from Orthologs
Summary
PMID 21209316
[Homo sapiens] CCDC88A, an activator of GNAI3, plays a key role in regulating autophagy; the dynamic interplay between GNAI3, GPSM1 and CCDC88A determines whether autophagy is promoted or inhibited. When stimulated by growth factors, CCDC88A disrupts the GNAI3::GPSM1 complex, subsequently enhancing anti-autophagy signalling pathways and inhibits autophagy by activating GNAI3.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115355:
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:29373658-29510808
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000040182 ENSMUSP00000048978
ENSMUST00000109477 ENSMUSP00000105103
ENSMUST00000137227
ENSMUST00000155854 ENSMUSP00000115117
ENSMUST00000123561 ENSMUSP00000119173
ENSMUST00000140194 ENSMUSP00000114942
ENSMUST00000144450
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0035091 phosphatidylinositol binding
GO:0042803 protein homodimerization activity
GO:0043422 protein kinase B binding
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0006260 DNA replication
GO:0006275 regulation of DNA replication
GO:0010975 regulation of neuron projection development
GO:0016477 cell migration
GO:0030032 lamellipodium assembly
GO:0031929 TOR signaling
GO:0032148 activation of protein kinase B activity
GO:0032956 regulation of actin cytoskeleton organization
GO:0042127 regulation of cell proliferation
GO:0045087 innate immune response (InnateDB)
GO:0061024 membrane organization
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030027 lamellipodium
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115355
View Gene Order
ENSBTAG00000017469
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.338284 Mm.396037 Mm.400876 Mm.402251
RefSeq NM_176841
OMIM
CCDS CCDS24494
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca