InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rpl10a

Summary

InnateDB Gene

IDBG-158227.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rpl10a

Gene Name

ribosomal protein L10A

Synonyms

CsA-19; Nedd6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037805

Encoded Proteins

IDBP-158229

ribosomal protein L10A

IDBP-536334

ribosomal protein L10A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198755:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:28328471-28331032

Strand

Forward strand

Band

A3.3

Transcripts

ENSMUST00000042334	ENSMUSP00000048469
ENSMUST00000128758
ENSMUST00000129935	ENSMUSP00000114141
ENSMUST00000152665
ENSMUST00000143443
ENSMUST00000150103
ENSMUST00000141049

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 88 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	88 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006412

translation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0015934	large ribosomal subunit
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0070062	extracellular vesicular exosome