Homo sapiens Gene: ATP8A1
Summary
InnateDB Gene IDBG-15848.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP8A1
Gene Name ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
Synonyms ATPASEII; ATPIA; ATPP2;
Species Homo sapiens
Ensembl Gene ENSG00000124406
Encoded Proteins
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily catalyzes transport of heavy metal ions. Another subfamily transports non-heavy metal ions (NMHI). The protein encoded by this gene is a member of the third subfamily of P-type ATPases and acts to transport amphipaths, such as phosphatidylserine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:42408373-42657105
Strand Reverse strand
Band p13
Transcripts
ENST00000381668 ENSP00000371084
ENST00000264449 ENSP00000264449
ENST00000514372 ENSP00000426495
ENST00000511858
ENST00000506602 ENSP00000421164
ENST00000515872 ENSP00000426935
ENST00000506713
ENST00000504510
ENST00000504024 ENSP00000427295
ENST00000510289 ENSP00000426636
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004012 phospholipid-translocating ATPase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019829 cation-transporting ATPase activity
GO:0046872 metal ion binding
Biological Process
GO:0006812 cation transport
GO:0008152 metabolic process
GO:0015914 phospholipid transport
GO:0034220 ion transmembrane transport
GO:0045332 phospholipid translocation
GO:0055085 transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042584 chromaffin granule membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Ion transport by P-type ATPases pathway
Ion channel transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H0YAA1
UniProt Splice Variant
Entrez Gene 10396
UniGene Hs.435052
RefSeq NM_001105529 NM_006095 XM_005248043 XM_006713989
HUGO HGNC:13531
OMIM 609542
CCDS CCDS3466 CCDS47049
HPRD 16527
IMGT
EMBL AC084010 AC096734 AC110788 AC139717
GenPept
RNA Seq Atlas 10396