InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP8A1

Summary

InnateDB Gene

IDBG-15848.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP8A1

Gene Name

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1

Synonyms

ATPASEII; ATPIA; ATPP2

Species

Homo sapiens

Ensembl Gene

ENSG00000124406

Encoded Proteins

IDBP-15850

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1

IDBP-15856

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1

IDBP-477524

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1

IDBP-481479

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1

IDBP-483978

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1

IDBP-480393

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1

IDBP-473526

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily catalyzes transport of heavy metal ions. Another subfamily transports non-heavy metal ions (NMHI). The protein encoded by this gene is a member of the third subfamily of P-type ATPases and acts to transport amphipaths, such as phosphatidylserine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:42408373-42657105

Strand

Reverse strand

Band

p13

Transcripts

ENST00000381668	ENSP00000371084
ENST00000264449	ENSP00000264449
ENST00000514372	ENSP00000426495
ENST00000511858
ENST00000506602	ENSP00000421164
ENST00000515872	ENSP00000426935
ENST00000506713
ENST00000504510
ENST00000504024	ENSP00000427295
ENST00000510289	ENSP00000426636

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004012	phospholipid-translocating ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006812	cation transport
GO:0008152	metabolic process
GO:0015914	phospholipid transport
GO:0034220	ion transmembrane transport
GO:0045332	phospholipid translocation
GO:0055085	transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042584	chromaffin granule membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000037685

View Gene Order

ENSBTAG00000011156

Not yet available

Pathways

NETPATH

REACTOME

REACT_25149

Ion transport by P-type ATPases pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.435052

RefSeq

NM_001105529 NM_006095 XM_005248043 XM_006713989

HUGO

OMIM

CCDS

CCDS3466 CCDS47049

HPRD

16527

IMGT

EMBL

GenPept

RNA Seq Atlas