Mus musculus Gene: Fos
Summary
InnateDB Gene IDBG-158538.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fos
Gene Name FBJ osteosarcoma oncogene
Synonyms c-fos; cFos; D12Rfj1
Species Mus musculus
Ensembl Gene ENSMUSG00000021250
Encoded Proteins
FBJ osteosarcoma oncogene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170345:
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:85473890-85477273
Strand Forward strand
Band D2
Transcripts
ENSMUST00000021674 ENSMUSP00000021674
ENSMUST00000140525
ENSMUST00000136122
ENSMUST00000134311
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 154 interaction(s) predicted by orthology.
Experimentally validated
Total 61 [view]
Protein-Protein 35 [view]
Protein-DNA 26 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 154 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0070412 R-SMAD binding
Biological Process
GO:0001661 conditioned taste aversion
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007399 nervous system development
GO:0007565 female pregnancy
GO:0007568 aging
GO:0009409 response to cold
GO:0009416 response to light stimulus
GO:0009612 response to mechanical stimulus
GO:0009629 response to gravity
GO:0009636 response to toxic substance
GO:0014070 response to organic cyclic compound
GO:0030431 sleep
GO:0031668 cellular response to extracellular stimulus
GO:0032496 response to lipopolysaccharide
GO:0032570 response to progesterone
GO:0032870 cellular response to hormone stimulus
GO:0034097 response to cytokine
GO:0034614 cellular response to reactive oxygen species
GO:0035902 response to immobilization stress
GO:0035914 skeletal muscle cell differentiation
GO:0042493 response to drug
GO:0045672 positive regulation of osteoclast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051412 response to corticosterone
GO:0051591 response to cAMP
GO:0060395 SMAD protein signal transduction
GO:0071277 cellular response to calcium ion
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0016020 membrane
GO:0043005 neuron projection
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Oxidative Stress Induced Senescence pathway
Activation of the AP-1 family of transcription factors pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
Cellular responses to stress pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Cellular Senescence pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
Toll-Like Receptors Cascades pathway
MyD88 dependent cascade initiated on endosome pathway
Activated TLR4 signalling pathway
MyD88-independent cascade pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
FCERI mediated MAPK activation pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Colorectal cancer pathway
MAPK signaling pathway pathway
B cell receptor signaling pathway pathway
Pathways in cancer pathway
Leishmaniasis pathway
Osteoclast differentiation pathway
Chagas disease (American trypanosomiasis) pathway
INOH
CD4 T cell receptor signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Alpha6Beta4Integrin pathway
EGFR1 pathway
TGF_beta_Receptor pathway
TCR pathway
BCR pathway
IL6 pathway
Prolactin pathway
Oncostatin_M pathway
REACTOME
Activation of the AP-1 family of transcription factors pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Cellular responses to stress pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Fc epsilon receptor (FCERI) signaling pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Cellular Senescence pathway
Activated TLR4 signalling pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Oxidative Stress Induced Senescence pathway
FCERI mediated MAPK activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Activated TLR4 signalling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88-independent cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Cellular responses to stress pathway
Immune System pathway
MAP kinase activation in TLR cascade pathway
Toll-Like Receptors Cascades pathway
Cellular Senescence pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Oxidative Stress Induced Senescence pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MyD88 dependent cascade initiated on endosome pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
Innate Immune System pathway
FCERI mediated MAPK activation pathway
Activation of the AP-1 family of transcription factors pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
MyD88 cascade initiated on plasma membrane pathway
KEGG
Colorectal cancer pathway
MAPK signaling pathway pathway
B cell receptor signaling pathway pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Pathways in cancer pathway
Leishmaniasis pathway
Chagas disease (American trypanosomiasis) pathway
Osteoclast differentiation pathway
INOH
CD4 T cell receptor signaling pathway
PID NCI
Calcium signaling in the CD4+ TCR pathway
Nongenotropic Androgen signaling
Trk receptor signaling mediated by the MAPK pathway
LPA receptor mediated events
IL2-mediated signaling events
Presenilin action in Notch and Wnt signaling
Downstream signaling in na´ve CD8+ T cells
S1P2 pathway
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
ErbB1 downstream signaling
ATF-2 transcription factor network
IL12 signaling mediated by STAT4
AP-1 transcription factor network
Glucocorticoid receptor regulatory network
FGF signaling pathway
Endothelins
BCR signaling pathway
Ras signaling in the CD4+ TCR pathway
ErbB2/ErbB3 signaling events
Regulation of nuclear SMAD2/3 signaling
HIF-1-alpha transcription factor network
GMCSF-mediated signaling events
RhoA signaling pathway
Fc-epsilon receptor I signaling in mast cells
FOXM1 transcription factor network
FOXA1 transcription factor network
PDGFR-alpha signaling pathway
PDGFR-beta signaling pathway
IL6-mediated signaling events
Regulation of Telomerase
Osteopontin-mediated events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.246513
RefSeq NM_010234
OMIM
CCDS CCDS26059
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas