Homo sapiens Gene: C1S
Summary
InnateDB Gene IDBG-15857.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C1S
Gene Name complement component 1, s subcomponent
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000182326
Encoded Proteins
complement component 1, s subcomponent
complement component 1, s subcomponent
complement component 1, s subcomponent
complement component 1, s subcomponent
complement component 1, s subcomponent
complement component 1, s subcomponent
complement component 1, s subcomponent
complement component 1, s subcomponent
complement component 1, s subcomponent
complement component 1, s subcomponent
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
C1S associates with C1R and C1Q to form the first component (C1) of the classical complement pathway.
C1S is the modular serine protease responsible for cleavage of C4 and C2, the protein substrates for the first component (C1).
Entrez Gene
Summary This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:6988259-7071032
Strand Forward strand
Band p13.31
Transcripts
ENST00000328916 ENSP00000328173
ENST00000360817 ENSP00000354057
ENST00000402681 ENSP00000384171
ENST00000406697 ENSP00000385035
ENST00000403949 ENSP00000384464
ENST00000413211 ENSP00000406643
ENST00000423384 ENSP00000399892
ENST00000443875 ENSP00000397921
ENST00000489541
ENST00000488701
ENST00000495053
ENST00000463798
ENST00000473545
ENST00000470326
ENST00000461983
ENST00000495061
ENST00000497061
ENST00000541647
ENST00000543187
ENST00000542978 ENSP00000442298
ENST00000617865 ENSP00000484657
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 15 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006508 proteolysis
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Classical antibody-mediated complement activation pathway
Creation of C4 and C2 activators pathway
Immune System pathway
Complement cascade pathway
Initial triggering of complement pathway
KEGG
Complement and coagulation cascades pathway
Staphylococcus aureus infection pathway
Systemic lupus erythematosus pathway
INOH
PID BIOCARTA
Classical complement pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.458355
RefSeq NM_001734 NM_201442 XM_005253760
HUGO
OMIM
CCDS CCDS31735
HPRD 00397
IMGT
EMBL
GenPept
RNA Seq Atlas