Version 5.4
Mus musculus Gene: Ptges2
Summary
InnateDB Gene IDBG-160124.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptges2
Gene Name prostaglandin E synthase 2
Synonyms 0610038H10Rik; C79137; Gbf1; Mpges2; Pges2
Species Mus musculus
Ensembl Gene ENSMUSG00000026820
Encoded Proteins
IDBP-160126
prostaglandin E synthase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21247892
Ptges2 is responsible for nearly half of the increment in NO production by alveolar macrophages in response to LPS stimulation. The enhancing effect of Ptges2 on NO production is mediated through the ligation of Ptger2 and acting via PKA to induce cAMP production. In addition Ptges2 induces expression of cytokines Il10 and Il6, while inhibiting Tnfa. (Demonstrated in rat models)
InnateDB Annotation from Orthologs
Summary
PMID 21247892
[Homo sapiens] PTGES2 is responsible for nearly half of the increment in NO production by alveolar macrophages in response to LPS stimulation. The enhancing effect of PTGES2 on NO production is mediated through the ligation of PTGER2 and acting via PKA to induce cAMP production. In addition PTGES2 induces expression of cytokines IL10 and IL6, while inhibiting TNFA. (Demonstrated in rat models)
Entrez Gene
Summary The protein encoded by this gene is a Golgi membrane-associated prostaglandin E synthase candidate, which is capable of catalyzing the conversion of prostaglandin H2 to prostaglandin E2 in vitro. However, a study using mice deficient of this gene suggests that this enzyme does not contribute to prostaglandin E2 biosynthesis in vivo. This protein is synthesized as a Golgi membrane-bound protein, but its N-terminal hydrophobic region is cleaved off during protein maturation to produce the predominant soluble truncated form that still retains the enzyme activity. This soluble protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE), possibly via an interaction with CAAAT/enhancer-binding protein-beta. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:32395896-32402739
Strand Forward strand
Band B
Transcripts
ENSMUST00000028162 ENSMUSP00000028162
ENSMUST00000123714
ENSMUST00000130121
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0009055 electron carrier activity
GO:0015035 protein disulfide oxidoreductase activity
GO:0016829 lyase activity
GO:0020037 heme binding
GO:0043295 glutathione binding
GO:0050220 prostaglandin-E synthase activity
Biological Process
GO:0001516 prostaglandin biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045454 cell redox homeostasis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046903 secretion
GO:0055114 oxidation-reduction process
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000148334
View Gene Order
ENSBTAG00000016218
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00590
Arachidonic acid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00590
Arachidonic acid metabolism pathway
INOH
INOH website
Prostaglandin Leukotriene metabolism pathway
PID NCI
ifngpathway
IFN-gamma pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.28048
RefSeq NM_133783
OMIM
CCDS CCDS15914
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca