Mus musculus Gene: Cct3
Summary
InnateDB Gene IDBG-160136.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cct3
Gene Name chaperonin containing Tcp1, subunit 3 (gamma)
Synonyms AL024092; Cctg; Tcp1-rs3; TriC-P5;
Species Mus musculus
Ensembl Gene ENSMUSG00000001416
Encoded Proteins
chaperonin containing Tcp1, subunit 3 (gamma)
chaperonin containing Tcp1, subunit 3 (gamma)
chaperonin containing Tcp1, subunit 3 (gamma)
chaperonin containing Tcp1, subunit 3 (gamma)
chaperonin containing Tcp1, subunit 3 (gamma)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163468:
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:88297116-88321767
Strand Forward strand
Band F1
Transcripts
ENSMUST00000001452 ENSMUSP00000001452
ENSMUST00000167000
ENSMUST00000164783
ENSMUST00000167718
ENSMUST00000164166 ENSMUSP00000126109
ENSMUST00000168062 ENSMUSP00000131113
ENSMUST00000163735 ENSMUSP00000130616
ENSMUST00000164122
ENSMUST00000168971 ENSMUSP00000131250
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 93 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 93 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0044822 poly(A) RNA binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0007339 binding of sperm to zona pellucida
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0002199 zona pellucida receptor complex
GO:0005737 cytoplasm
GO:0005832 chaperonin-containing T-complex
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0044297 cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Chaperonin-mediated protein folding pathway
Association of TriC/CCT with target proteins during biosynthesis pathway
Folding of actin by CCT/TriC pathway
Metabolism of proteins pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
Protein folding pathway
Formation of tubulin folding intermediates by CCT/TriC pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Formation of tubulin folding intermediates by CCT/TriC pathway
Protein folding pathway
Folding of actin by CCT/TriC pathway
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
Association of TriC/CCT with target proteins during biosynthesis pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
Folding of actin by CCT/TriC pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
Protein folding pathway
Association of TriC/CCT with target proteins during biosynthesis pathway
Formation of tubulin folding intermediates by CCT/TriC pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.256034 Mm.394384 Mm.454079 Mm.469258
RefSeq NM_009836
OMIM
CCDS CCDS17468
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas