Version 5.4
Mus musculus Gene: Blvrb
Summary
InnateDB Gene IDBG-161057.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Blvrb
Gene Name biliverdin reductase B (flavin reductase (NADPH))
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000040466
Encoded Proteins
IDBP-161059
biliverdin reductase B (flavin reductase (NADPH))
IDBP-264707
biliverdin reductase B (flavin reductase (NADPH))
IDBP-264709
biliverdin reductase B (flavin reductase (NADPH))
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090013:
The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:27447978-27466144
Strand Forward strand
Band A3
Transcripts
ENSMUST00000037399 ENSMUSP00000043092
ENSMUST00000108358 ENSMUSP00000103995
ENSMUST00000108357 ENSMUSP00000103994
ENSMUST00000133750
ENSMUST00000153644
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0004074 biliverdin reductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042602 riboflavin reductase (NADPH) activity
GO:0050662 coenzyme binding
Biological Process
GO:0006694 steroid biosynthetic process
GO:0042167 heme catabolic process
GO:0044237 cellular metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000090013
View Gene Order
ENSBTAG00000010508
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_233393
Heme degradation pathway
REACT_233360
Metabolism of porphyrins pathway
KEGG
mmu00860
Porphyrin and chlorophyll metabolism pathway
mmu00740
Riboflavin metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22297
Heme degradation pathway
REACT_9431
Metabolism of porphyrins pathway
REACT_111217
Metabolism pathway
REACT_208785
Heme degradation pathway
REACT_210300
Metabolism of porphyrins pathway
REACT_219139
Metabolism pathway
KEGG
hsa00740
Riboflavin metabolism pathway
hsa00860
Porphyrin and chlorophyll metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001290525 NM_144923 XM_006539861
OMIM
CCDS CCDS39848 CCDS71922
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca