Mus musculus Gene: Atp6v1a
Summary
InnateDB Gene IDBG-161436.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atp6v1a
Gene Name ATPase, H+ transporting, lysosomal V1 subunit A
Synonyms AI647066; Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2;
Species Mus musculus
Ensembl Gene ENSMUSG00000052459
Encoded Proteins
ATPase, H+ transporting, lysosomal V1 subunit A
ATPase, H+ transporting, lysosomal V1 subunit A
ATPase, H+ transporting, lysosomal V1 subunit A
ATPase, H+ transporting, lysosomal V1 subunit A
ATPase, H+ transporting, lysosomal V1 subunit A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114573:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq, Jul 2008]
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c\', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:44085402-44139705
Strand Reverse strand
Band B4
Transcripts
ENSMUST00000063661 ENSMUSP00000066886
ENSMUST00000114666 ENSMUSP00000110314
ENSMUST00000130036
ENSMUST00000137557 ENSMUSP00000116923
ENSMUST00000124102 ENSMUSP00000118429
ENSMUST00000147025 ENSMUSP00000118726
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0015991 ATP hydrolysis coupled proton transport
GO:0015992 proton transport
GO:0046034 ATP metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0016324 apical plasma membrane
GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain
GO:0033180 proton-transporting V-type ATPase, V1 domain
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Disease pathway
Signaling by Insulin receptor pathway
Transferrin endocytosis and recycling pathway
Phagosomal maturation (early endosomal stage) pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Iron uptake and transport pathway
Transmembrane transport of small molecules pathway
Insulin receptor recycling pathway
Signal Transduction pathway
KEGG
Oxidative phosphorylation pathway
Phagosome pathway
Collecting duct acid secretion pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Iron uptake and transport pathway
Insulin receptor recycling pathway
Signal Transduction pathway
Transferrin endocytosis and recycling pathway
Phagosomal maturation (early endosomal stage) pathway
Signaling by Insulin receptor pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Disease pathway
Transferrin endocytosis and recycling pathway
Phagosomal maturation (early endosomal stage) pathway
Iron uptake and transport pathway
Transmembrane transport of small molecules pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Signal Transduction pathway
Signaling by Insulin receptor pathway
Insulin receptor recycling pathway
Disease pathway
KEGG
Oxidative phosphorylation pathway
Phagosome pathway
Collecting duct acid secretion pathway
Vibrio cholerae infection pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.217787 Mm.397717 Mm.472398
RefSeq NM_007508 XM_006521720 XM_006521721
OMIM
CCDS CCDS28182
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas