InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Maff

Summary

InnateDB Gene

IDBG-161506.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Maff

Gene Name

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000042622

Encoded Proteins

IDBP-161508

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)

IDBP-621107

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185022:
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:79347541-79359072

Strand

Forward strand

Band

Transcripts

ENSMUST00000096350	ENSMUSP00000094076
ENSMUST00000163691	ENSMUSP00000131628

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0035914	skeletal muscle cell differentiation
GO:0045604	regulation of epidermal cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000185022

View Gene Order

ENSBTAG00000021435

Not yet available

Pathways

NETPATH

REACTOME

REACT_224553

Hemostasis pathway

REACT_198649

Factors involved in megakaryocyte development and platelet production pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_604

Hemostasis pathway

REACT_215067

Factors involved in megakaryocyte development and platelet production pathway

REACT_212196

Hemostasis pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

O54791

TrEMBL

Q3U0G5

UniProt Splice Variant

Entrez Gene

17133

UniGene

Mm.86646

RefSeq

NM_010755 XM_006520546 XM_006520547 XM_006520548 XM_006520549 XM_006520550

OMIM

CCDS

CCDS27638

HPRD

IMGT

MGI ID

MGI:96910

MGI Symbol

Maff

EMBL

AB009694 AK146043 AK156896 BC022952 CH466550

GenPept

AAH22952 BAA24029 BAE26855 BAE33888 EDL04655

RNA Seq Atlas

17133