Version 5.4
Homo sapiens Gene: IFITM1
Summary
InnateDB Gene IDBG-16232.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFITM1
Gene Name interferon induced transmembrane protein 1
Synonyms 9-27; CD225; DSPA2a; IFI17; LEU13
Species Homo sapiens
Ensembl Gene ENSG00000185885
Encoded Proteins
IDBP-16234
interferon induced transmembrane protein 1 (9-27)
IDBP-292469
interferon induced transmembrane protein 1 (9-27)
IDBP-592738
interferon induced transmembrane protein 1 (9-27)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20064371
IFITM1 is an antiviral restriction factor that mediates cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus by inhibiting their early replication.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:313506-315272
Strand Forward strand
Band p15.5
Transcripts
ENST00000328221 ENSP00000330825
ENST00000408968 ENSP00000386187
ENST00000528780 ENSP00000437057
ENST00000525554
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 5 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
Biological Process
GO:0001503 ossification
GO:0007166 cell surface receptor signaling pathway
GO:0008285 negative regulation of cell proliferation
GO:0009607 response to biotic stimulus
GO:0009615 response to virus
GO:0019221 cytokine-mediated signaling pathway
GO:0030336 negative regulation of cell migration
GO:0034341 response to interferon-gamma
GO:0035455 response to interferon-alpha
GO:0035456 response to interferon-beta
GO:0035556 intracellular signal transduction
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0045669 positive regulation of osteoblast differentiation
GO:0046597 negative regulation of viral entry into host cell
GO:0050776 regulation of immune response
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
NetPath_12
BCR pathway
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_25162
Interferon alpha/beta signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04662
B cell receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_003641
HUGO
OMIM
CCDS CCDS41584
HPRD 05122
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca