Version 5.4
Mus musculus Gene: Cdkn2a
Summary
InnateDB Gene IDBG-162905.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdkn2a
Gene Name cyclin-dependent kinase inhibitor 2A
Synonyms Arf; ARF-INK4a; INK4a-ARF; Ink4a/Arf; MTS1; p16; p16(INK4a); p16INK4a; p19; p19ARF; Pctr1;
Species Mus musculus
Ensembl Gene ENSMUSG00000044303
Encoded Proteins
IDBP-162907
cyclin-dependent kinase inhibitor 2A
IDBP-267341
cyclin-dependent kinase inhibitor 2A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22095712
The tumour suppressor Cdkn2a plays a role in innate immunity as a regulator of inflammatory cell signalling. Cdkn2a null mice were unable to trigger a proper inflammatory response in experimental peritonitis or in induced edema and were resistant to LPS-induced endotoxic shock.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 4:89274471-89294653
Strand Reverse strand
Band C4
Transcripts
ENSMUST00000060501 ENSMUSP00000061847
ENSMUST00000107131 ENSMUSP00000102748
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
Experimentally validated
Total 77 [view]
Protein-Protein 65 [view]
Protein-DNA 11 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 protein binding
GO:0055105 ubiquitin-protein transferase inhibitor activity
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000209 protein polyubiquitination
GO:0006355 regulation of transcription, DNA-templated
GO:0006364 rRNA processing
GO:0006915 apoptotic process
GO:0007050 cell cycle arrest
GO:0007568 aging
GO:0007569 cell aging
GO:0008544 epidermis development
GO:0009303 rRNA transcription
GO:0010468 regulation of gene expression
GO:0030308 negative regulation of cell growth
GO:0030889 negative regulation of B cell proliferation
GO:0031647 regulation of protein stability
GO:0033088 negative regulation of immature T cell proliferation in thymus
GO:0033600 negative regulation of mammary gland epithelial cell proliferation
GO:0034393 positive regulation of smooth muscle cell apoptotic process
GO:0035019 somatic stem cell maintenance
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045087 innate immune response (InnateDB)
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045786 negative regulation of cell cycle
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046822 regulation of nucleocytoplasmic transport
GO:0048103 somatic stem cell division
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0060058 positive regulation of apoptotic process involved in mammary gland involution
GO:0070301 cellular response to hydrogen peroxide
GO:0070534 protein K63-linked ubiquitination
GO:2000111 positive regulation of macrophage apoptotic process
Cellular Component
GO:0001652 granular component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
mmu04110
Cell cycle pathway
mmu04115
p53 signaling pathway pathway
mmu05200
Pathways in cancer pathway
mmu05212
Pancreatic cancer pathway
mmu05214
Glioma pathway
mmu05218
Melanoma pathway
mmu05219
Bladder cancer pathway
mmu05220
Chronic myeloid leukemia pathway
mmu05223
Non-small cell lung cancer pathway
INOH
INOH website
Hedgehog signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P51480 Q64364
TrEMBL A7LP29 Q9QWT5
UniProt Splice Variant
Entrez Gene 12578
UniGene Mm.4733
RefSeq NM_001040654 NM_009877
OMIM
CCDS CCDS18350 CCDS38812
HPRD
IMGT
MGI ID MGI:104738
MGI Symbol Cdkn2a
EMBL AF004588 AF044335 AF044336 AF115545 AF120108 AF332190 AJ238890 AK155307 AL831719 BC058190 EU071702 L76092 L76150 S80650 U49279 U49280 U49281 U49282 U66086 U66087 U79625 U79626 U79627 U79628 U79630 U79631 U79632
GenPept AAA85453 AAB35770 AAB39600 AAB61416 AAC00051 AAC00052 AAC00053 AAC00054 AAC08962 AAC08963 AAC42080 AAD00223 AAD00224 AAD00225 AAD00226 AAD00227 AAD00228 AAD00229 AAD11438 AAD33245 AAH58190 AAK83159 ABS85193 BAE33180 CAB65598 CAM16002 CAM16003
RNA Seq Atlas 12578

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca