Mus musculus Gene: Fbxw2
Summary
InnateDB Gene IDBG-163313.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxw2
Gene Name F-box and WD-40 domain protein 2
Synonyms 2700071L08Rik; FBW2; Fwd2; MD6
Species Mus musculus
Ensembl Gene ENSMUSG00000035949
Encoded Proteins
F-box and WD-40 domain protein 2
F-box and WD-40 domain protein 2
F-box and WD-40 domain protein 2
F-box and WD-40 domain protein 2
F-box and WD-40 domain protein 2
F-box and WD-40 domain protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119402:
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:34804514-34826311
Strand Reverse strand
Band B
Transcripts
ENSMUST00000028220 ENSMUSP00000028220
ENSMUST00000091020 ENSMUSP00000088541
ENSMUST00000113080 ENSMUSP00000108703
ENSMUST00000113078 ENSMUSP00000108701
ENSMUST00000113077 ENSMUSP00000108700
ENSMUST00000113075 ENSMUSP00000108698
ENSMUST00000156130
ENSMUST00000145180
ENSMUST00000131534
ENSMUST00000145660
ENSMUST00000134323
ENSMUST00000150865
ENSMUST00000126051
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Association of TriC/CCT with target proteins during biosynthesis pathway
Protein folding pathway
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.473328 Mm.483160
RefSeq NM_001164768 NM_001164769 NM_001164770 NM_013890 XM_006498117 XM_006498118
OMIM
CCDS CCDS15952 CCDS50573 CCDS50574
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas