InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CENPJ

Summary

InnateDB Gene

IDBG-16356.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CENPJ

Gene Name

centromere protein J

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000151849

Encoded Proteins

IDBP-16358

centromere protein J

IDBP-362127

centromere protein J

IDBP-597685

centromere protein J

IDBP-806605

centromere protein J

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:24882284-24922889

Strand

Reverse strand

Band

q12.13

Transcripts

ENST00000381884	ENSP00000371308
ENST00000418179	ENSP00000399334
ENST00000471870
ENST00000493190
ENST00000545981	ENSP00000441090
ENST00000616936	ENSP00000477511

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015631	tubulin binding
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0007020	microtubule nucleation
GO:0007099	centriole replication
GO:0046599	regulation of centriole replication
GO:0046785	microtubule polymerization
GO:0051301	cell division