Mus musculus Gene: Pak4
Summary
InnateDB Gene IDBG-163840.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pak4
Gene Name p21 protein (Cdc42/Rac)-activated kinase 4
Synonyms 5730488L07Rik; AW555722; mKIAA1142;
Species Mus musculus
Ensembl Gene ENSMUSG00000030602
Encoded Proteins
p21 protein (Cdc42/Rac)-activated kinase 4
p21 protein (Cdc42/Rac)-activated kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130669:
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:28399549-28598185
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000032823 ENSMUSP00000032823
ENSMUST00000108283 ENSMUSP00000103918
ENSMUST00000135923
ENSMUST00000150454
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0008150 biological_process
GO:0023014 signal transduction by phosphorylation
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by Robo receptor pathway
Axon guidance pathway
Developmental Biology pathway
Activation of Rac pathway
KEGG
ErbB signaling pathway pathway
Axon guidance pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
Regulation of actin cytoskeleton pathway
Renal cell carcinoma pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Developmental Biology pathway
Axon guidance pathway
Activation of Rac pathway
Signaling by Robo receptor pathway
KEGG
ErbB signaling pathway pathway
Axon guidance pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
Regulation of actin cytoskeleton pathway
Renal cell carcinoma pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Agrin in postsynaptic differentiation [Biocarta view]
PID NCI
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
FGF signaling pathway
CDC42 signaling events
Cross-References
SwissProt Q8BTW9
TrEMBL
UniProt Splice Variant
Entrez Gene 70584
UniGene Mm.21876
RefSeq NM_027470 NM_175021 XM_006540356
OMIM
CCDS CCDS21049 CCDS21044
HPRD
IMGT
MGI ID MGI:1917834
MGI Symbol Pak4
EMBL AK017713 AK088512 AK129298 AY217016 BC048238
GenPept AAH48238 AAO61496 BAB30889 BAC40396 BAC98108
RNA Seq Atlas 233033 70584