Homo sapiens Gene: RTN4R
Summary
InnateDB Gene IDBG-1645.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RTN4R
Gene Name reticulon 4 receptor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000040608
Encoded Proteins
reticulon 4 receptor
reticulon 4 receptor
reticulon 4 receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:20241415-20283246
Strand Reverse strand
Band q11.21
Transcripts
ENST00000043402 ENSP00000043402
ENST00000416372 ENSP00000396872
ENST00000425986 ENSP00000403535
ENST00000469601
ENST00000474642
ENST00000463936
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0007409 axonogenesis
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050770 regulation of axonogenesis
GO:0050771 negative regulation of axonogenesis
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0031225 anchored component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Signalling by NGF pathway
p75NTR regulates axonogenesis pathway
p75 NTR receptor-mediated signalling pathway
Axonal growth inhibition (RHOA activation) pathway
Signal Transduction pathway
KEGG
INOH
PID BIOCARTA
PID NCI
p75(NTR)-mediated signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.30868
RefSeq NM_023004
HUGO
OMIM
CCDS CCDS13777
HPRD 16123
IMGT
EMBL
GenPept
RNA Seq Atlas