Version 5.4
Homo sapiens Gene: RTN4R
Summary
InnateDB Gene IDBG-1645.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RTN4R
Gene Name reticulon 4 receptor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000040608
Encoded Proteins
IDBP-1647
reticulon 4 receptor
IDBP-362894
reticulon 4 receptor
IDBP-362896
reticulon 4 receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:20241415-20283246
Strand Reverse strand
Band q11.21
Transcripts
ENST00000043402 ENSP00000043402
ENST00000416372 ENSP00000396872
ENST00000425986 ENSP00000403535
ENST00000469601
ENST00000474642
ENST00000463936
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0007409 axonogenesis
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050770 regulation of axonogenesis
GO:0050771 negative regulation of axonogenesis
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0031225 anchored component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000043811
View Gene Order
Pathways
NETPATH
REACTOME
REACT_13815
Axonal growth inhibition (RHOA activation) pathway
REACT_11061
Signalling by NGF pathway
REACT_13620
p75NTR regulates axonogenesis pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
p75ntrpathway
p75(NTR)-mediated signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.30868
RefSeq NM_023004
HUGO
OMIM
CCDS CCDS13777
HPRD 16123
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca