Version 5.4
| Homo sapiens Gene: CLEC4C | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-16472.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | CLEC4C | ||||||||||||||||||
| Gene Name | C-type lectin domain family 4, member C | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000198178 | ||||||||||||||||||
| Encoded Proteins |
C-type lectin domain family 4, member C
C-type lectin domain family 4, member C
C-type lectin domain family 4, member C
C-type lectin domain family 4, member C
C-type lectin domain family 4, member C
C-type lectin domain family 4, member C
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
CLEC4C (BDCA-2) signalling inhibits TLR-9-agonist-induced plasmacytoid dendritic cell activation (through the inhibition of CD86 and CD40) and antigen presentation.
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| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 12:7729415-7751605 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p13.31 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q8WTT0 | ||||||||||||||||||
| TrEMBL | H0YFH6 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 170482 | ||||||||||||||||||
| UniGene | Hs.351812 | ||||||||||||||||||
| RefSeq | NM_130441 NM_203503 | ||||||||||||||||||
| HUGO | HGNC:13258 | ||||||||||||||||||
| OMIM | 606677 | ||||||||||||||||||
| CCDS | CCDS8583 CCDS8584 | ||||||||||||||||||
| HPRD | 09453 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC006517 AF293615 AF325459 AF325460 AY358223 BC074967 BC074968 BC102015 BC102016 BC102017 BC114338 CH471116 | ||||||||||||||||||
| GenPept | AAH74967 AAH74968 AAI02016 AAI02017 AAI02018 AAI14339 AAL37036 AAL37358 AAL37359 AAQ88590 EAW88655 EAW88656 | ||||||||||||||||||
| RNA Seq Atlas | 170482 | ||||||||||||||||||