Version 5.4
Mus musculus Gene: Anxa4
Summary
InnateDB Gene IDBG-165108.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Anxa4
Gene Name annexin A4
Synonyms AI265406; AIV; Anx4; AW106930; Xanx-4
Species Mus musculus
Ensembl Gene ENSMUSG00000029994
Encoded Proteins
IDBP-165110
annexin A4
IDBP-253376
annexin A4
IDBP-788965
annexin A4
IDBP-535254
annexin A4
IDBP-533610
annexin A4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20237821
[Homo sapiens] ANXA4 differentially modulates the NF-kappaB signalling pathway and this is dependent on its interactions with NFKB1 and the intracellular Ca(2+) ion level.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196975:
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. [provided by RefSeq, Jul 2008]
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59%% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:86736840-86793584
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000001187 ENSMUSP00000001187
ENSMUST00000113675 ENSMUSP00000109305
ENSMUST00000127152 ENSMUSP00000138194
ENSMUST00000135921
ENSMUST00000155456 ENSMUSP00000117378
ENSMUST00000123732 ENSMUSP00000115346
ENSMUST00000129772
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0042802 identical protein binding
GO:0048306 calcium-dependent protein binding
GO:0051059 NF-kappaB binding
Biological Process
GO:0001822 kidney development
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0030855 epithelial cell differentiation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:2000483 negative regulation of interleukin-8 secretion
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0012506 vesicle membrane
GO:0016324 apical plasma membrane
GO:0031965 nuclear membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000196975
View Gene Order
ENSBTAG00000001105
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3Z0S1
UniProt Splice Variant
Entrez Gene 11746
UniGene Mm.259702 Mm.418704
RefSeq NM_013471 XM_006505397 XM_006505398 XM_006505399
OMIM
CCDS CCDS39543
HPRD
IMGT
MGI ID MGI:88030
MGI Symbol Anxa4
EMBL AC157099 AC158662
GenPept
RNA Seq Atlas 11746

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca