Version 5.4
Mus musculus Gene: Akap8
Summary
InnateDB Gene IDBG-165421.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Akap8
Gene Name A kinase (PRKA) anchor protein 8
Synonyms 1200016A02Rik; AA673585; AKAP95; AU015639
Species Mus musculus
Ensembl Gene ENSMUSG00000024045
Encoded Proteins
IDBP-165423
A kinase (PRKA) anchor protein 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105127:
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:32303676-32321153
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000002699 ENSMUSP00000002699
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0034237 protein kinase A regulatory subunit binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007076 mitotic chromosome condensation
Cellular Component
GO:0000793 condensed chromosome
GO:0001939 female pronucleus
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016363 nuclear matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105127
View Gene Order
ENSBTAG00000001807
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.473124
RefSeq NM_019774 XM_006524663 XM_006524664 XM_006524665
OMIM
CCDS CCDS37555
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca