InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Xrcc5

Summary

InnateDB Gene

IDBG-165686.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Xrcc5

Gene Name

X-ray repair complementing defective repair in Chinese hamster cells 5

Synonyms

AI314015; Ku80; Ku86

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026187

Encoded Proteins

IDBP-165688

X-ray repair complementing defective repair in Chinese hamster cells 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24098118

[Homo sapiens] Vaccinia virus protein C16 influences the immune response by binding to the XRCC6/XRCC5 (Ku70/80) complex thus blocking PRKDC-dependent DNA sensing in fibroblasts

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000079246:
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:72307421-72394952

Strand

Forward strand

Band

Transcripts

ENSMUST00000027379

ENSMUSP00000027379

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 159 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	159 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003690	double-stranded DNA binding
GO:0003691	double-stranded telomeric DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0031625	ubiquitin protein ligase binding
GO:0044212	transcription regulatory region DNA binding
GO:0044822	poly(A) RNA binding
GO:0051575	5'-deoxyribose-5-phosphate lyase activity

Biological Process

GO:0000723	telomere maintenance
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006310	DNA recombination
GO:0006351	transcription, DNA-templated
GO:0007420	brain development
GO:0008283	cell proliferation
GO:0032508	DNA duplex unwinding
GO:0042493	response to drug
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050769	positive regulation of neurogenesis
GO:0060218	hematopoietic stem cell differentiation
GO:0071398	cellular response to fatty acid
GO:0071475	cellular hyperosmotic salinity response
GO:0071481	cellular response to X-ray

Cellular Component

GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0043234	protein complex
GO:0043564	Ku70:Ku80 complex
GO:0070419	nonhomologous end joining complex