Version 5.4
Mus musculus Gene: Ftcd
Summary
InnateDB Gene IDBG-165898.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ftcd
Gene Name formiminotransferase cyclodeaminase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000001155
Encoded Proteins
IDBP-165900
formiminotransferase cyclodeaminase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160282:
The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:76575648-76590338
Strand Forward strand
Band C1
Transcripts
ENSMUST00000001183 ENSMUSP00000001183
ENSMUST00000137347
ENSMUST00000146344
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005542 folic acid binding
GO:0016740 transferase activity
GO:0030409 glutamate formimidoyltransferase activity
GO:0030412 formimidoyltetrahydrofolate cyclodeaminase activity
Biological Process
GO:0006548 histidine catabolic process
GO:0007010 cytoskeleton organization
GO:0008152 metabolic process
GO:0019556 histidine catabolic process to glutamate and formamide
GO:0019557 histidine catabolic process to glutamate and formate
GO:0035999 tetrahydrofolate interconversion
GO:0044237 cellular metabolic process
Cellular Component
GO:0005794 Golgi apparatus
GO:0005814 centriole
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000160282
View Gene Order
ENSBTAG00000020404
Not yet available
Pathways
NETPATH
REACTOME
REACT_236760
Histidine catabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
KEGG
mmu00340
Histidine metabolism pathway
mmu00670
One carbon pool by folate pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1249
Histidine catabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00670
One carbon pool by folate pathway
hsa00340
Histidine metabolism pathway
INOH
INOH website
Folate metabolism pathway
INOH website
Histidine degradation pathway
PID NCI
Cross-References
SwissProt Q91XD4
TrEMBL
UniProt Splice Variant
Entrez Gene 14317
UniGene Mm.36278
RefSeq NM_080845 XM_006513215
OMIM
CCDS CCDS23950
HPRD
IMGT
MGI ID MGI:1339962
MGI Symbol Ftcd
EMBL BC010813 BC024078
GenPept AAH10813 AAH24078
RNA Seq Atlas 14317

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca