Homo sapiens Gene: GABRB1
Summary
InnateDB Gene IDBG-16651.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GABRB1
Gene Name gamma-aminobutyric acid (GABA) A receptor, beta 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163288
Encoded Proteins
gamma-aminobutyric acid (GABA) A receptor, beta 1
gamma-aminobutyric acid (GABA) A receptor, beta 1
gamma-aminobutyric acid (GABA) A receptor, beta 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:46993723-47426444
Strand Forward strand
Band p12
Transcripts
ENST00000295454 ENSP00000295454
ENST00000381582
ENST00000513567 ENSP00000426753
ENST00000509366
ENST00000510909 ENSP00000426766
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004890 GABA-A receptor activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005254 chloride channel activity
GO:0015276 ligand-gated ion channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071420 cellular response to histamine
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
GO:1902711 GABA-A receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Ligand-gated ion channel transport pathway
Neuronal System pathway
GABA receptor activation pathway
Orphan transporters pathway
Ion channel transport pathway
Transmission across Chemical Synapses pathway
GABA A receptor activation pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL D6REL3
UniProt Splice Variant
Entrez Gene 2560
UniGene
RefSeq NM_000812
HUGO HGNC:4081
OMIM 137190
CCDS CCDS3474
HPRD 15924
IMGT
EMBL AC097712 AC105394 AC107383 AC107392 KJ535054
GenPept AHW56693
RNA Seq Atlas 2560